Karl Tryggvason Selected Research

nephrin

1/2017	Wolf-Hirschhorn syndrome candidate 1-like 1 epigenetically regulates nephrin gene expression.
6/2011	The podocyte protein nephrin is required for cardiac vessel formation.
1/2010	Permeability, ultrastructural changes, and distribution of novel proteins in the glomerular barrier in early puromycin aminonucleoside nephrosis.
1/2010	Nephrin is expressed on the surface of insulin vesicles and facilitates glucose-stimulated insulin release.
2/2009	Expression of galectin-1, a new component of slit diaphragm, is altered in minimal change nephrotic syndrome.
9/2007	Mizoribine corrects defective nephrin biogenesis by restoring intracellular energy balance.
11/2004	Nephrin strands contribute to a porous slit diaphragm scaffold as revealed by electron tomography.
7/2004	Defective trafficking of nephrin missense mutants rescued by a chemical chaperone.
5/2004	Tissue expression of nephrin in human and pig.
2/2004	Monoclonal antibodies to human nephrin.

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Karl Tryggvason Research Topics

Disease

19	Proteinuria 01/2017 - 02/2001
13	Nephrotic Syndrome (Syndrome, Nephrotic) 01/2017 - 06/2000
9	Neoplasms (Cancer) 10/2009 - 05/2002
8	Kidney Diseases (Kidney Disease) 01/2020 - 02/2001
6	Focal Segmental Glomerulosclerosis (Glomerulosclerosis, Focal) 10/2021 - 02/2001
6	Diabetic Nephropathies (Diabetic Nephropathy) 01/2020 - 01/2010
5	Fibrosis (Cirrhosis) 10/2021 - 01/2006
5	Nephrosis 01/2017 - 02/2001
5	Inflammation (Inflammations) 01/2016 - 07/2004
5	Hereditary Nephritis (Alport Syndrome) 11/2014 - 04/2000
5	Lipoid Nephrosis (Glomerulonephritis, Minimal Change) 09/2014 - 03/2002
4	Albuminuria 10/2021 - 01/2011
4	Neoplasm Metastasis (Metastasis) 05/2011 - 06/2002
4	congenital Nephrosis 11/2004 - 02/2001
3	Hypoxia (Hypoxemia) 01/2018 - 01/2006
3	Laminopathies 12/2012 - 05/2002
3	Inborn Genetic Diseases (Disease, Hereditary) 02/2004 - 04/2000
3	Nephritis 10/2003 - 04/2000
2	Infarction (Infarctions) 05/2020 - 01/2019
2	Wounds and Injuries (Trauma) 01/2020 - 01/2004
2	Infections 12/2018 - 06/2009
2	Renal Insufficiency (Renal Failure) 08/2015 - 10/2011
2	Chronic Kidney Failure (Chronic Renal Failure) 08/2015 - 09/2012
2	Disease Progression 11/2014 - 10/2007
2	Ischemia 11/2014 - 01/2006
2	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 06/2014 - 08/2012
2	Weight Gain 01/2014 - 03/2004
2	Body Weight (Weight, Body) 12/2012 - 03/2004
2	Craniofacial Abnormalities 06/2012 - 01/2003
2	Carcinoma (Carcinomatosis) 10/2009 - 06/2002
2	Pneumonia (Pneumonitis) 03/2007 - 07/2004
2	Hearing Loss (Hearing Impairment) 10/2003 - 04/2000
2	IGA Glomerulonephritis (IGA Nephropathy) 03/2002 - 02/2001
2	Membranous Glomerulonephritis (Membranous Nephropathy) 03/2002 - 02/2001
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2022
1	Burns 01/2020
1	Junctional Epidermolysis Bullosa (Epidermolysis Bullosa Letalis) 01/2020
1	Teratoma (Teratoid Tumor) 01/2019
1	Yellow Fever 12/2018
1	Starvation 01/2018
1	Pierson syndrome 01/2018
1	Necrosis 01/2018
1	Wolf-Hirschhorn Syndrome 01/2017
1	Peritoneal Fibrosis 01/2017
1	Vascular System Injuries 08/2014
1	Obesity 01/2014
1	Connective Tissue Diseases (Connective Tissue Disease) 05/2013
1	Cysts 01/2013

Drug/Important Bio-Agent (IBA)

20	nephrinIBA 01/2017 - 06/2000
17	Proteins (Proteins, Gene)FDA Link 01/2020 - 02/2002
13	Laminin (Merosin)IBA 01/2022 - 02/2002
5	Heparitin Sulfate (Heparan Sulfate)IBA 11/2014 - 03/2004
4	Protein Isoforms (Isoforms)IBA 01/2020 - 06/2002
4	Matrix Metalloproteinases (MMPs)IBA 01/2017 - 05/2002
4	Collagen Type IV (Type IV Collagen)IBA 11/2014 - 04/2000
4	perlecanIBA 11/2014 - 03/2004
4	Puromycin AminonucleosideIBA 09/2014 - 09/2007
4	Scavenger Receptors (Scavenger Receptor)IBA 05/2013 - 07/2004
4	IntegrinsIBA 05/2011 - 01/2006
3	dendrinIBA 08/2015 - 08/2008
3	AntibodiesIBA 10/2009 - 02/2002
3	KalininIBA 11/2007 - 06/2002
3	NPHS2 proteinIBA 11/2004 - 02/2002
2	Streptozocin (Streptozotocin)FDA Link 01/2021 - 01/2016
2	DNA (Deoxyribonucleic Acid)IBA 01/2020 - 07/2005
2	Messenger RNA (mRNA)IBA 01/2017 - 02/2001
2	LipopolysaccharidesIBA 01/2016 - 01/2009
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 11/2014 - 01/2006
2	AlbuminsIBA 06/2014 - 01/2011
2	AutoantibodiesIBA 05/2013 - 10/2007
2	Matrix Metalloproteinase 14 (MT1-MMP)IBA 06/2012 - 01/2003
2	laminin 10IBA 05/2011 - 11/2007
2	CollagenIBA 12/2010 - 10/2009
2	Blocking AntibodiesIBA 10/2009 - 11/2007
2	CytokinesIBA 06/2009 - 07/2004
2	LipidsIBA 07/2008 - 03/2007
2	Lamin Type A (Lamin A)IBA 07/2005 - 05/2002
2	laminin 8IBA 04/2005 - 06/2004
1	HemosiderinIBA 10/2021
1	Protein Kinase CIBA 01/2020
1	Recombinant ProteinsIBA 01/2019
1	Attenuated VaccinesIBA 12/2018
1	VaccinesIBA 12/2018
1	InterferonsIBA 12/2018
1	SuspensionsIBA 01/2018
1	Mechanistic Target of Rapamycin Complex 1IBA 01/2018
1	Tyrosine (L-Tyrosine)FDA Link 01/2018
1	Biocompatible Materials (Biomaterials)IBA 01/2017
1	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2017
1	Semaphorins (Semaphorin)IBA 01/2016
1	MorpholinosIBA 01/2015
1	Heparan Sulfate Proteoglycans (Heparan Sulfate Proteoglycan)IBA 11/2014
1	Doxorubicin (Adriamycin)FDA LinkGeneric 09/2014
1	Proteoglycans (Proteoglycan)IBA 08/2014
1	ForminsIBA 02/2013

Therapy/Procedure

6	Therapeutics 01/2020 - 03/2009
3	Transplantation 01/2020 - 05/2006
2	Kidney Transplantation 09/2012 - 05/2006
1	Islets of Langerhans Transplantation 01/2018
1	Renal Replacement Therapy (Therapies, Renal Replacement) 08/2015